Personal Information
Research Associate Professor
Deputy Director of the Research Center
School of Life Sciences,
Shaanxi Normal University,
Xi’an 710062, China
E-mail: yuan.xie@snnu.edu.cn
Education
2012 – 2016 Ph. D in basic medicine, Uppsala University, Sweden
2009 – 2011 M. S. in applied biotechnology, Uppsala University, Sweden
2005 – 2009 B. S. in life sciences, Shaanxi Normal University, China
Professional Experience
2019--present Associate Professor of Life Sciences, College of Life Sciences, Shaanxi Normal University
2016---2018 Postdoc Researcher in Medical Science, Department of Immunology, Genetics and Pathology, Uppsala University, Sweden
Awards
2022 The title of Excellent Internship Leading Teacher of Shaanxi normal university
2021 The second prize of the 13th Young Teachers' Teaching Basic Skills Competition of Shaanxi Normal University
2020 The title of Undergraduate Excellent Graduation Thesis Instructor
Research Project
1. Study on the Mechanism of LGR5 Signaling Pathway in Glioma Stem Cell with respect to Self-renewal capacity; Youth Project of National Natural Science Foundation of China; 82002659; 2021/01-2023/12.
2. Research on the Key Signal Pathway of Self-renewal Mechanism of Human Glioma Stem Cell; The Youth Project of Natural Science Foundation of Shaanxi Province, 2020JQ-429; 2020/01-2021/12.
3. Research on the Regulatory Mechanism of the Origin of Malignant Glioma Stem Cells; Fundamental Research Funds for the Central Universities; GK202003048 2020/01-2021/12.
Research Interests
1. Explore the key genes involved in the formation, development and recurrence of malignant glioma, and conduct experimental verification in various mouse glioma models such as HGCC resource library and RCAS/TVA model.
2. To explore the signaling pathway of glioma stem cell marker LGR5, identify the key downstream molecules of LGR5, and construct a signaling network based on LGR5 regulation.
3.Through the analysis of the transcriptome and methylation sequencing of cells before and after treatment, to explore the treatment resistance mechanism glioma stem cells of different cell origins to temozolomide combined with radiation therapy.
Representative Publications
1. Xie Y, He L, Lugano R, et al. Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing. JCI Insight (2021); IF：9.484
2. Xie Y, Sundström A, Maturi NP, et al. LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients. Journal of Pathology (2019); IF:9.883
3. Xie Y, Bergström T, Jiang Y, et al. The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes. EBioMedicine (2015); IF:11.205
4. Sreedharan S, Maturi NP, Xie Y, et al. Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype. Cancer Research (2017); IF:13.312 (equal contribution)
5. Zhang Y, Xie Y, He L, et al. 1p/19q co-deletion status is associated with distinct tumor-associated macrophage infiltration in IDH mutated lower-grade gliomas. Cellular Oncology (2021); IF:7.051 (equal contribution)